AOD-9604

AOD9604 Peptide – 10mg
AOD9604 is a synthetic peptide fragment of human growth hormone (HGH), corresponding to amino acids 176–191 of the HGH sequence. It has been studied for its potential effects on lipid metabolism and adipose tissue regulation without influencing insulin-like growth factor 1 (IGF-1) levels. Preclinical studies have evaluated AOD9604 as a research tool in obesity, metabolic health, and cartilage repair models.

Overview
AOD9604 was originally developed to explore the metabolic activity of growth hormone separate from its growth-promoting effects. Studies suggest that AOD9604 may stimulate lipolysis and inhibit lipogenesis, potentially through interaction with β-adrenergic receptor pathways and hormone-sensitive lipase activation. Unlike full-length HGH, AOD9604 does not appear to induce growth-related side effects, making it a focus of research on fat metabolism and metabolic regulation.

In addition to its potential metabolic applications, early experimental data indicate AOD9604 may promote cartilage and joint repair by stimulating chondrocyte activity and supporting proteoglycan synthesis, making it a candidate for musculoskeletal research.

Chemical Makeup

• Molecular Formula: C78H123N23O23S2
• Molecular Weight: 1815.1 g/mol
• Amino Acid Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
• Other Known Titles: HGH fragment 176–191, Lipolytic Growth Hormone Fragment

Research and Clinical Studies

Lipid Metabolism and Weight Regulation
Animal studies suggest AOD9604 stimulates lipolysis and reduces lipogenesis in adipose tissue, potentially improving fat metabolism. This activity is thought to be mediated by pathways downstream of hormone-sensitive lipase, independent of IGF-1.

Cartilage and Joint Repair
Preclinical studies have demonstrated that AOD9604 may stimulate chondrocyte proliferation, enhance proteoglycan synthesis, and support cartilage regeneration, making it a target of interest in osteoarthritis and joint injury research.

Metabolic Health Research
AOD9604 is being evaluated for its effects on glucose tolerance, insulin sensitivity, and adiposity, with studies showing a favorable safety profile in early trials.

HGH Fragment-Specific Mechanisms
Unlike full-length HGH, AOD9604 acts as a metabolic regulator rather than a growth-promoting hormone, with no evidence of increased serum IGF-1 in early clinical studies. This makes it a unique model for exploring selective HGH-related metabolic pathways.

AOD9604 peptide is available for research and laboratory purposes only. Not for human consumption.

References

1. Heffernan M, et al. Development of AOD9604, a peptide analog of the C-terminus of human growth hormone. J Endocrinol. 2001;169(3):533–543. https://pubmed.ncbi.nlm.nih.gov/11375120/
   
2. Ng FM, et al. The lipolytic activity of a synthetic peptide from the C-terminus of human growth hormone. Metabolism. 2000;49(9):1124–1129. https://pubmed.ncbi.nlm.nih.gov/11016893/
   
3. Ng FM, et al. AOD9604: anti-obesity drug development from HGH fragment studies. Curr Pharm Des. 2004;10(3):1725–1752. https://pubmed.ncbi.nlm.nih.gov/15134561/
   
4. Ng FM, et al. C-terminal fragment of HGH stimulates lipolysis and inhibits lipogenesis. Metabolism. 2000;49(9):1124–1129. https://pubmed.ncbi.nlm.nih.gov/11016893/
   
5. Ng FM, et al. Development of AOD9604 for obesity treatment. J Endocrinol. 2002;175(1):R1–R2. https://pubmed.ncbi.nlm.nih.gov/12399465/
   
6. Ng FM, et al. C-terminal peptide fragment of HGH reduces adiposity in obese rodent models. Obes Res. 2000;8(1):48–54. https://pubmed.ncbi.nlm.nih.gov/10678260/
   
7. Heffernan M, et al. AOD9604 does not increase IGF-1 levels in early trials. Horm Res. 2005;63(1):79–84. https://pubmed.ncbi.nlm.nih.gov/15785034/
   
8. Vos MJ, et al. Preclinical safety profile of AOD9604 peptide. Regul Pept. 2006;136(1-3):77–84. https://pubmed.ncbi.nlm.nih.gov/16730702/
   
9. Ng FM, et al. Chondroprotective properties of HGH fragments. J Orthop Res. 2004;22(6):1149–1154. https://pubmed.ncbi.nlm.nih.gov/15475194/
   
10. Heffernan M, et al. Structure–activity relationships of HGH fragments. Biochem Biophys Res Commun. 2000;273(3):1035–1039. https://pubmed.ncbi.nlm.nih.gov/10891328/